Peeling Back the Onion of Cyber Espionage after Tallinn 2.0

Tallinn 2.0 represents an important advancement in the understanding of international law’s application to cyber operations below the threshold of force. Its provisions on cyber espionage will be instrumental to states in grappling with complex legal problems in the area of digital spying. The law of cyber espionage as outlined by Tallinn 2.0, however, is substantially based on rules that have evolved outside of the digital context, and there exist serious ambiguities and limitations in its framework. This Article will explore gaps in the legal structure and consider future options available to states in light of this underlying mismatch

Are Energy Efficiency Standards Justified?

This paper develops and parameterizes an overarching analytical framework to estimate the welfare effects of energy efficiency standards applied to automobiles and electricity-using durables. We also compare standards with sectoral and economywide pricing policies. The model captures a wide range of externalities and preexisting energy policies, and it allows for possible “misperceptions”—market failures that cause underinvestment in energy efficiency.Automobile fuel economy standards are not part of the first-best policy to reduce gasoline: fuel taxes are always superior because they reduce the externalities related to vehicle miles traveled. For the power sector, potential welfare gains from supplementing pricing instruments with efficiency standards are small at best. If pricing instruments are not feasible, a large misperceptions failure is required to justify efficiency standards, and even in this case the optimal reductions in fuel and electricity use are relatively modest. Reducing economywide carbon dioxide emissions through regulatory packages (combining efficiency and emissions standards) involves much higher costs than pricing instruments.standards, energy taxes, market failure, climate, power sector, gasoline

Three-dimensional structure of basal body triplet revealed by electron cryo-tomography.

Basal bodies and centrioles play central roles in microtubule (MT)-organizing centres within many eukaryotes. They share a barrel-shaped cylindrical structure composed of nine MT triplet blades. Here, we report the structure of the basal body triplet at 33 Å resolution obtained by electron cryo-tomography and 3D subtomogram averaging. By fitting the atomic structure of tubulin into the EM density, we built a pseudo-atomic model of the tubulin protofilaments at the core of the triplet. The 3D density map reveals additional densities that represent non-tubulin proteins attached to the triplet, including a large inner circular structure in the basal body lumen, which functions as a scaffold to stabilize the entire basal body barrel. We found clear longitudinal structural variations along the basal body, suggesting a sequential and coordinated assembly mechanism. We propose a model in which δ-tubulin and other components participate in the assembly of the basal body

Distal occurrence of mid-Holocene Whakatane Tephra on the Chatham Islands, New Zealand, and potential for cryptotephra studies

The Whakatane Tephra, a rhyolitic tephra erupted ca. 5500 cal. BP from Okataina Volcanic Centre, central North Island, has been identified on the Chatham Islands which lie ˜900 km east of Christchurch, New Zealand. The visible tephra layer, ˜5 mm in thickness and preserved within peat on Pitt Island, was identified using both radiocarbon dating and analysis of glass shards by electron microprobe. Whakatane Tephra is the first Holocene tephra to be identified on the Chatham Islands, and it is the most distal Holocene tephra yet recorded in the New Zealand region, being ˜850 km from source. The Pitt Island occurrence extends the tephra's dispersal area markedly, by an order of magnitude, possibly to ˜300,000 km2. An estimated dispersal index (D) of approximately 105 km2 indicates that the eruption generated a very high plinian column, possibly exceeding ˜30 km in height, with strong winds blowing the ash plume southeastwards. This new discovery of distal Whakatane Tephra as a thin but visible layer strongly implies that cryptotephras are likely to be preserved on the Chatham Islands and within adjacent ocean floor sediments. Therefore the potential exists to develop enhanced cryptotephrostratigraphic records from these distal areas, which in turn would help facilitate precise correlation via tephrochronology of palaeoenvironmental records (such as NZ-INTIMATE) from mainland New Zealand, the southwest Pacific Ocean, and the Chatham Islands

Practical experiences with regression analysis

https://egrove.olemiss.edu/dl_proceedings/1090/thumbnail.jp

A planning program and the design for a single enterprise community in the Subarctic

Thesis (M.C.P.) Massachusetts Institute of Technology. Dept. of Architecture, 1956.ACCOMPANYING drawings held by MIT Museum.Includes bibliographies.by James Arthur Hatcher and David Dunsmore Wallace.M.C.P

Topical decolonization does not eradicate the skin microbiota of community-dwelling or hospitalized adults

Topical antimicrobials are often employed for decolonization and infection prevention and may alter the endogenous microbiota of the skin. The objective of this study was to compare the microbial communities and levels of richness and diversity in community-dwelling subjects and intensive care unit (ICU) patients before and after the use of topical decolonization protocols. We enrolled 15 adults at risk for Staphylococcus aureus infection. Community subjects (n = 8) underwent a 5-day decolonization protocol (twice daily intranasal mupirocin and daily dilute bleach-water baths), and ICU patients (n = 7) received daily chlorhexidine baths. Swab samples were collected from 5 anatomic sites immediately before and again after decolonization. A variety of culture media and incubation environments were used to recover bacteria and fungi; isolates were identified using matrix-assisted laser desorption ionization–time of flight mass spectrometry. Overall, 174 unique organisms were recovered. Unique communities of organisms were recovered from the community-dwelling and hospitalized cohorts. In the community-dwelling cohort, microbial richness and diversity did not differ significantly between collections across time points, although the number of body sites colonized with S. aureus decreased significantly over time (P = 0.004). Within the hospitalized cohort, richness and diversity decreased over time compared to those for the enrollment sampling (from enrollment to final sampling, P = 0.01 for both richness and diversity). Topical antimicrobials reduced the burden of S. aureus while preserving other components of the skin and nasal microbiota

Emphysema : the challenge of the remodelled lung

Emphysema is recognized as the component of chronic obstructive airways disease that is responsible for airways obstruction. Different patterns of emphysema are, however, recognized, suggesting possible different pathogenetic processes within the lung. This, coupled with the associated idea of susceptibility factors to the development of emphysema, has led to studies of genes that may be involved in the defence of the lung from proteolytic and oxidative damage. These studies have been driven by the goal of finding a treatment for emphysema, but appear to have lost sight of the fundamental remodelling of the lung that has occurred in patients with emphysema and the fact that it is not a single morphological entity.peer-reviewe